The issue of online security has recently become especially relevant in connection with systematic data leaks and account hacks. Many companies offer 2-Step Verification, and most of the methods work through short codes sent to the phone via SMS. You can call this method convenient (some even believe in the high security of SMS codes), nevertheless, automatic distribution sometimes fails and makes the user wait for a long time. Google offers a similar method of protection, but the search giant has a great alternative - Google Authenticator.
This application, which acts as a conditional center for sending SMS messages with codes, is only always at hand and does not require a network connection. The best part is that it can be configured not only for corporate accounts, but also for any private user.
First, you need to make sure that 2-Step Verification is connected to your account. To do this, you need to go to, click "Proceed to setup" and specify your phone number, if it has not been linked earlier. Then we follow the instructions and go through simple steps. If two-step authorization is already active, then go to the connection point of the application itself.
1 - 4
We take to take the main device, which is always at hand. Usually, this is a smartphone. Next, download the Google Authenticator app to or. Unfortunately, now I only have an iPhone, so the example will be shown on it, but the process in an Android smartphone is not one iota different.
After that, we go through one more and see a screen on which there is a choice of a device for obtaining a code (the second protection factor). Now the method of receiving the code in the form of SMS is active, and below there is an item on which the button "Switch to app" we need is located. Click, select a smartphone with the platform used and see the screen with Barcode. Now go to the recently downloaded Google Authenticator application, press "+" and scan the code. At the end of the procedure, a card appears in the application with a systematically updated 6-digit password, which is entered as the second factor.
1 - 4
Of course, memorizing even six characters is not always convenient (although it is useful for training the brain), because Google has provided an excellent option - when you hold it on the card, a context menu appears with the ability to copy the password.
The advantages of using Google Authenticator are obvious - you are not tied to the presence of the network - although now it is difficult to find such a place where there is no signal reception, and also do not depend on the performance of the password distribution service (which periodically sends codes with a noticeable delay).
The next difficulty is connecting some applications for which two authorization factors are not available - a number of email clients, favorite calendars, and so on. You can connect to them using Application Passwords. Google has written detailed and understandable instructions, so I don't see any point in repeating the text, you can just familiarize yourself with it. The password must be entered once, you will not have to return to it again, that is, you do not need to remember or write it down anywhere.
1 - 3
For those who are not convinced by the above text in the usability of the application, I can give, as it seems to me, the most important argument - this way I get into my work account. And you can connect a number of services in this way. Rather, the word "series" is meant here as a huge variety of popular services where two-step authentication is available. For example, such a service can be an unknown cloud service Dropbox. it is described how to do this, so I will tell you briefly: go to your account, go to the account settings, go to the "Security" item, press the "Enable" button in the "Two-step verification" section. Then we enter our password, check the box "Use the program for mobile devices". We repeat the steps with scanning the Barcode in the application on the smartphone, click "Next", enter the code from the application, get an emergency recovery code, which should be written down, then write down where you wrote it down, and remember the place that keeps the secret about the location of the password.
Despite the above example, there are a great many services that offer the ability to secure data using a double factor. There are cases when you are given a "secret" - a long rubbish associated with your account, which you just need to enter in the "Enter manually" item after pressing the "+" key in the application itself. The essence of this does not change - the second factor is entered in the same place as the code that previously came in the form of SMS.
I hope that a relatively large amount of text will save a lot more nerves and time in the future when entering codes that previously came in the form of SMS. And of course, it will make the use of your accounts more secure.
Download Google Authenticator app:
I'll show you how to play World of tanks on Android and iOS. Thus, you can play with your account in tanks and on your smartphone or tablet on Android and on iPhone or iPad. I will also show you how to protect your account in World of tanks by linking it to your mobile phone number.
First of all, if you have many accounts on your smartphone or tablet, then at the first start you can always choose which account you want to use on your device to play World of tanks.
Click on the top left to open the game settings, then click on "Account".
The game developer's website and your personal account at Wargaming will open. Come up with a password for your account and confirm it by entering it again, then click "add".
Ready. Now you have a username and password for your World Of Tanks account.
Now, having downloaded World Of Tanks on Android or iOS, you can click enter with a password to play with your account.
Enter your email address to which you linked your account and the password that you came up with for your World Of Tanks account, then click "Login".
For playing on different operating systems (Android, iOS) and creating a password for your account, you will be given 250 gold coins.
If you launched the game on iOS, then click on the Game Center slider in the game account settings to link your account to the Game Center on iOS (this is an analogue of the Play Games service on Android, which saves your game progress) so that you always continue the game on different devices with your Apple iD account.
Congratulations! You have successfully added your Game Center link to your account. Now you can use this opportunity to enter the game. If you play GTA: San Andreas, you can also play it on Android and iOS. This is described and shown in the article.
2. We link the World Of Tanks account to the phone number
Now, so that no one steals or hacks your account in World of tanks, we will bind it to your mobile phone number. To do this, go to the site of the game developer World of tanks at Wargaming.net and click "Login".
Enter your email address to which you have linked your World of tanks game account and enter the password that you came up with for the game account, then click "Login".
You will log in with your account on the site, now click on "Personal Account" to open your account settings for the game World of tanks.
Here click on "Link to phone number".
Go to the mail and you will see a letter from the developer of the game World of tanks with a link to link your account to a mobile phone number. Click Link Account.
A page on Wargaming.net will open with an account linking to a mobile phone number. Enter your country and your mobile phone, then click "Continue".
Check if you entered your number correctly and if yes, then click "Get SMS code", if not, then click "correct number".
A confirmation code will be sent to the number you specified.
Enter the code received on your number and click "Activate".
Ready. Your account has been successfully linked to your mobile phone number. Click Close.
A similar linking and account transfer can be done with the Clash Of Clans game. This is shown in the article.
3. Connect the second factor of protection
For maximum security of your World of tanks account, you can enable a second protection factor, which is even cooler than two-step authentication. All important actions performed with your account will require a randomly generated code and no one will be able to buy or sell something without this code.
On the World of tanks Wargaming.net game developer's page in your personal account, you will also be able to enable the second factor of protecting your account. Click "Connect".
To connect the second protection factor, you must confirm the operation with an SMS code. Click "Continue" - a code will be sent to your mobile phone number. The application is available only for devices with iOS and Android operating systems.
You will receive an SMS code from Wargaming.
Enter it on the Wargaming.net page and click "Activate".
Now download the Google Authenticator application to your smartphone or tablet from the Play Market on Android or the AppStore on iOS and click "Next".
This is what it looks like in the AppStore. It generates random codes that can be used to perform various operations with your account in the World of tanks game. Also, this application is used by some payment systems (for example epayments).
Now after you have downloaded the Google Authenticator application to your smartphone or tablet, open it and scan the QR code displayed on the Wargaming.net page.
Open the Google Authenticator app on your tablet or smartphone and click on the plus sign from the top right.
After scanning, you will receive a six-digit code that will be valid for about 30 seconds, during which time you need to enter it on the Wargaming.net website, if you do not have time, the code will change.
Enter the generated code from the Google Authenticator app and click "Activate".
That's all. The second protection factor is successfully connected. Now you wear double protection on your account (like 2 condoms).
The second protection factor has been successfully connected to your Wargaming.net account. If you have not enabled the second factor of protection, please contact the Support Center.
That's all. There is a link to Goggle +, there is a Game Center, an account is linked to a phone number and a second protection factor is connected. Your account is under reliable protection and you can play on both iOS and Android in World of tanks.
Selling World of Tanks accounts step by step: instructions for creating an account + algorithms for binding the phone and the second protection factor + 4 tips for working with the game + TOP-10 sites for selling World of Tanks accounts.
World of tanks Is a game that has conquered the hearts of millions of netizens. Everyone can now afford to plunge into the world of combat battles on heavy armored vehicles - just take 10 minutes to create an account in World of Tanks and download the client to your computer.
Today we will talk not only about the registration procedure, but also touch on the topic of selling accounts. You will learn where you can place an advertisement for the sale, as well as how the transaction itself will be carried out.
World of Tanks - accounts in the game and how to create them
Before starting our journey in the world of WOT, we need our own account on the official website of the game. In addition to the standard accounting, the project provides expanded opportunities for certain groups of individuals (press accounts), as well as registration by invite codes.
We will analyze these questions a little later. Now, let's find out what a gamer needs to start the gameplay in the world of World of Tanks.
1. Preparatory stage.
Before registering and downloading the client, understand the performance indicators of your personal computer. WOT is an online client game, which means that to use it you will need a constant Internet connection and hardware that can cope with the loads on the system.
The first question is the characteristics of your PC. There is no point in downloading the game client and registering if your device simply cannot pull it. In the table below, we have submitted the minimum and optimal.
| Parameter | World of Tanks minimum system requirements | Recommended system requirements for World of Tanks |
|---|---|---|
| Operating system | Windows XP SP3, Windows Vista, Windows 7, Windows 8, Windows 10 | Windows XP SP3, Windows Vista, Windows 7, Windows 8, Windows 10 - 64-bit |
| Minimum screen resolution | 1024 × 768 dots | 1024 × 768 dots |
| Processor (CPU) | With two or more physical cores, supporting SSE2 technology | Intel Core i5-3330 |
| Random access memory (RAM) | 1.5 GB (Windows XP), 2 GB (Windows Vista, Windows 7, Windows 8, Windows 10) | 4 GB (or more) |
| Video adapter | GeForce 6800 / ATI HD 2400 XT with 256 MB memory, DirectX 9.0c | GeForce GTX660 (2GB) / Radeon HD 7850 2GB, DirectX 9.0c |
| Audio card | DirectX 9.0c compatible | DirectX 9.0c compatible |
| Free hard disk space | ~ 30 GB | ~ 45 GB |
| Internet connection speed | 256 kbps | 1024 kbps or higher (for voice chat) |
If the parameters of your device meet at least the minimum system requirements, we can move on.
Now we need a game client, which you can download on the project's official website. will not cause problems, but if you are afraid of accidentally making a mistake, use the step-by-step instructions provided below.
How to install the World of Tanks client - instructions for beginners:
Alternatively, you can download the game client via torrent and simply install it as a regular program. The volume of updated data will then be much less - from 500 MB to 2 GB.
After completing the installation process, we need our own World of Tanks account to enter the game through the client. We will talk further about how to register correctly in the project.
2. How to create an account in World of Tanks - the easiest way.
The only sure way to create an account in WOT is to register through the official website of the game. This is the only way you can protect your personal information and avoid the tricks of scammers who want to make money on the well-known project from Wargaming.Stages of registering an account through the official World of Tanks website:
You are now the full owner of the World of Tanks account. All that remains is to launch the game client and enter your login with a password - the WOT world will open for you in the very same second, and you can fully enjoy all the splendor of the Wargaming project.
3. How to create an account in World of Tanks with bonuses?
In addition to the standard way of creating an account in World of Tanks, users have the opportunity to receive various rewards and presents already at the start of their journey in the game.After registering your account and installing World of Tanks, read the tips to help protect yourself from intruders.
More and more resources appear on the Internet that are visually a copy of the official website (phishing sites). They were created with one purpose - to scam users for money. If you dare to buy gold or premium vehicles from similar websites, there is a 90% chance that nothing will be credited to your account in the game.
In order to protect yourself from tricks study the address bar carefully... Externally, the sites may be mirror images of each other, but the address will differ exactly. This is how the link to the official website of the project should look like: https://worldoftanks.ru/
They will not be of much use, since the changes are immediately recorded and after 1-2 days the account will simply be frozen. Third-party software only harms the servers, and, moreover, it can transfer your personal data on your account to unauthorized persons.
As a result, you will be left with a broken trough, and when blocked by IP, it will not make sense to create a new account, since access to the World of Tanks servers will also be closed to her.
Entering your account credentials for any purpose (buying gold, exchanging resources, and so on), carefully study the resource that gives you the opportunity to do this.It is possible that when sending data to the server, it will be intercepted, and the next time you log in, you will find that the old password is no longer valid.
No matter how strong the password is, you can never be 100% insured. Although periodic cyberattacks on the project's servers are successfully repelled, a partial leak of information still occurs.
There is no guarantee that the login and password from your World of Tanks account will not be present among the data released outside. By changing the security combination once a month, the user will be able to increase the security of the account by 30-40%.
In connection with the theft of accounts in the world of World of Tanks, the developers decided to add additional degrees of protection that can double the security of the account. Let's consider the algorithms for doing this in more detail.
Algorithm # 1 - binding a phone:
The key condition is having a phone number at hand. Everything about everything will take up to 7 minutes of personal time. Now, if any suspicious activity occurs on your account, you will immediately receive an alert not only by email, but also to the phone number associated with your account.
Algorithm # 2 - connecting the second protection factor:
Having connected additional authentication using the application, do not try to delete it, otherwise there will be a possibility of losing access to your account.
However, if any trouble does arise, you still have a mailbox. Using it, you can untie the mobile number or the second protection factor of the World of Tanks account.
Selling accounts in World of Tanks
If earlier the creation of accounts in World of Tanks was only a game direction, now many users on the network use the project for personal commercial purposes. You can create and upgrade an average account in 1-2 months of playing, and then sell it as a finished product using one of many methods.
What is worth knowing when selling accounts?
Selling a WOT account is not an easy task. If only because for this you will have to devote more than one day of your time to pumping the branches of the vehicle tree. It is much more difficult to find buyers for accounts without unique premium technology.
The average price for an account is formed from 2 parameters: the amount of money invested + personal time spent on pumping.
The second parameter is more subjective, and it is often because of it that the cost may be unreasonably high on the part of the seller. You can understand people: who wants to sell an account on the cheap, in which so much time and effort has been invested?
Algorithm for selling an account in World of Tanks:
- Collecting account information and compiling a high-quality product description.
- Placement of ads on various sites and search for a buyer.
- Discussion of the details of the transaction. It is possible to work through a guarantor.
- The exchange process itself: money to the buyer's account, and the account data to the buyer.
Before selling an account, you need to unlink the phone number and remove the second level of account protection, otherwise the new owner may have problems with this in the future.
Risks when selling an account for a seller:
- temporary transfer of data for a test ride can turn into account theft;
- the transfer of funds is carried out with protection, but after receiving data from the account, the buyer does not give you a password;
- the site administration finds out about the sale and blocks the account.
To protect yourself as much as possible, when selling accounts, use the services of trusted guarantors - do not trust the first one on the network, as the results can be disastrous.
Best Resources for Selling WOT Accounts
There are a lot of websites where you can sell / buy World of Tanks accounts, but the question is which ones are worth your attention and which ones are better to stay away from.
We have prepared for you the top of 10 proven resources on which the sale of accounts in World of Tanks will be safest.
№1. https://wot.accounts.name/catalo
A multifaceted site specializing in the sale of accounts of various projects on the network. Almost 2,000 ads run in the World of Tanks section on an ongoing basis.
A convenient filter and resource promotion provide large volumes of social traffic, which means that the chances of selling your game account here are very high. There is a built-in system for providing a guarantor for transactions.
№2. https://funpay.ru/lots/77/
An open area with various themes, among which the sale of accounts in World of Tanks is one of the key ones. The platform has sections in more than 70 different directions, and there are more than 4,000 sellers.
To submit an advertisement for the sale of an account, you must register. The site has more than 12,000 positive reviews, therefore the resource provides truly high-quality services, of which you can become a representative.
№3. http://wot-market.com/
A site with a narrow specialization, which was created specifically for the purpose of selling and buying accounts in World of Tanks. To submit an advertisement for a sale, you do not even need to register on the resource, but if you want to promote the product to the top of the list, you will have to replenish the system wallet and log in to the website.
Immediately, when selling an account, you can enlist the support of a guarantor.
№4. http://buytoplay.ru/obyavleniya/world-of-tank s
A gaming shopping site that has been operating since 2014 and has proven itself only from the best side. There is a feedback system, thanks to which it is convenient to sell World of Tanks accounts on an ongoing basis.
The user has the right to place an advertisement for sale for free, but in order to raise it to the top of the list, you will have to pay according to the platform's tariffs.
№5. http://www.pwlvl.ru/WorldOfTanks.html
Online games store, among which the World of Tanks section is one of the largest. To work with the resource, you need to register + it is desirable to have an electronic wallet in the Webmoney system - this will significantly simplify the replenishment of the intra-system account for additional operations with the ad.
Account sale is carried out directly. The site can provide the services of a guarantor to improve the security of the transaction.
№6. http://forums.goha.ru/
A thematic forum where you can search for sites for selling accounts in World of Tanks, and sell your account in the corresponding trading section.
To gain more trust from potential buyers, you will need to register and increase your personal rating by performing various tasks in the system (comments, reviews, and so on).
№7. http://www.market4game.ru/forums/world-of-tanks-rynok-akkauntov.142
Internet market of gaming topics selling accounts of various games, including World of Tanks. To work with the platform, you will need to register in the system.
Here you can not only sell accounts, but also put them up for exchange. The site values its reputation and tries in every possible way to get rid of the scams on its pages, therefore among gamers this is one of the priority resources for sale.
№8. http://garantmarket.net/witblitz m
A market that allows you to sell World of Tanks accounts through an intermediary. You can place an ad absolutely free of charge - it will be located not only on the resource pages, but also be duplicated in such social networks as VKontakte and Odnoklassniki.
A mobile version for Android is available, which will allow you to always be aware of the events on the sale of your account in WOT.
№9. http://newbrowsergames.ru/birja/world-of-tank s
The game exchange on which you can sell your World of Tanks account as soon as possible, since the popularity of this resource among users on the network is one of the highest. Each registered member has his own rating, which is developed gradually - a good option for constant sales.
The only drawback: a guarantor for transactions is not provided, therefore, for this purpose, you will have to look for a third-party resource.
№10. http://ocash.ru
A platform for the sale of game accounts, which has been operating since 2008, which already testifies to the conscientiousness of the resource. The sale is carried out through the intermediaries of the site for a certain percentage of the cost. The guarantor can be ordered immediately, which greatly simplifies the life of both the seller and the buyer.
You can also post ads on open areas of a general focus, such as Avito or NewAuction. Just find the appropriate section and place your ad for sale there. The likelihood of buying there is not so great, but as an alternative, it will do.
How to sell or buy a WOT account?
Errors, tips for selling and buying an account.
To make a sale go smoothly, there are some generally accepted principles that can improve product appeal and speed up the marketing process.
You can make a sale more effective if:
Increase the amount of initial information on the game account.
Buyers always want to see what they are buying. By putting up an account for sale with a minimal description, you yourself drive away customers without even realizing it.
Don't overcharge your account.
Study the supply and demand of the market in detail before putting up a product for sale. The disproportionately high cost must be confirmed by facts (high efficiency, the amount of donation, and so on).
Facilitate communication with the seller.
A Twitter page may not be the best way to contact a seller. This not only arouses suspicion on the part of the buyer of your account, but also forces you to reduce the number of views by 30-40%.
Phone number + skype + any social media account is the best solution.
Increase the number of ads you place
Try to sell your World of Tanks account with as many resources as possible. In total, your efforts can speed up the sale of your account by 2 or even 3 times.
Do not forget to use a guarantor, because deception is possible on the part of the buyer, for example:
- www.garant.pro
- garant-sdelok.ru
- https://garantbro.ru
Armed with our advice and instructions, you can successfully start selling World of Tanks accounts on a temporary or permanent basis.
We have discussed how to create an account in World of Tanks and how to sell it. Selling accounts or playing just for fun is up to you.
Two-factor authentication is based on the use of not only the traditional "login-password" link, but also an additional level of protection - the so-called second factor, the possession of which must be confirmed in order to gain access to an account or other data.
The simplest example of two-factor authentication that each of us constantly encounters is withdrawing cash from an ATM. To receive money, you need a card that only you have and a PIN that only you know. Having obtained your card, an attacker will not be able to withdraw cash without knowing the PIN-code, and in the same way he will not be able to receive money knowing it, but not having a card.
The same principle of two-factor authentication is used to access your social media accounts, mail and other services. The first factor is a combination of login and password, and the following 5 things can act as the second.
SMS codes
Ken Banks / flickr.comVerification using SMS codes is very simple. You, as usual, enter your username and password, after which an SMS comes to your phone number with a code that must be entered to enter your account. It's all. At the next login, another SMS code is sent, valid only for the current session.
Advantages
- Generation of new codes at each entry. If attackers intercept your username and password, they will not be able to do anything without the code.
- Binding to a phone number. Login is not possible without your phone.
disadvantages
- If there is no cellular signal, you will not be able to log in.
- There is a theoretical likelihood of changing the number through the service of the operator or employees of communication salons.
- If you log in and receive codes on the same device (for example, a smartphone), then the protection ceases to be two-factor.
Authenticator applications
authy.com This option is in many ways similar to the previous one, with the only difference that, instead of receiving codes via SMS, they are generated on the device using a special application (Google Authenticator, Authy). During setup, you receive a primary key (most often - in the form of a QR code), on the basis of which one-time passwords with a validity period of 30 to 60 seconds are generated using cryptographic algorithms. Even if we assume that attackers will be able to intercept 10, 100, or even 1,000 passwords, it is simply impossible to predict what the next password will be with their help.
Advantages
- The authenticator does not need a cellular signal; an Internet connection is enough during the initial setup.
- Support for multiple accounts in one authenticator.
disadvantages
- If attackers gain access to the primary key on your device or by hacking the server, they can generate future passwords.
- If you use an authenticator on the same device from which you are logging in, you lose two-factor.
Login verification using mobile apps
This type of authentication can be called a hodgepodge of all the previous ones. In this case, instead of asking for codes or one-time passwords, you must confirm the login from your mobile device with the service application installed. A private key is stored on the device, which is verified every time you log in. This works for Twitter, Snapchat and various online games. For example, when you log into your Twitter account in the web version, you enter your username and password, then a notification comes to your smartphone with a login request, after confirming which your feed opens in the browser.
Advantages
- You don't need to enter anything when you log in.
- Cellular independence.
- Support for multiple accounts in one application.
disadvantages
- If attackers intercept the private key, they can impersonate you.
- The meaning of two-factor authentication is lost when using the same login device.
Hardware Tokens
yubico.com Physical (or hardware) tokens are the most secure two-factor authentication method. As separate devices, hardware tokens, unlike all the methods listed above, will not lose their two-factor component under any circumstances. Most often they are presented in the form of USB dongles with their own processor that generates cryptographic keys that are automatically entered when connected to a computer. The choice of the key depends on the specific service. Google, for example, recommends using FIDO U2F tokens, prices for which start at $ 6 excluding shipping.
Advantages
- No SMS or apps.
- No need for a mobile device.
- It is a completely independent device.
disadvantages
- Must be purchased separately.
- Not supported in all services.
- When using multiple accounts, you will have to carry a whole bunch of tokens.
Backup keys
In fact, this is not a separate method, but a backup option in case of loss or theft of a smartphone, which receives one-time passwords or confirmation codes. When you set up two-factor authentication in each service, you are given several backup keys for emergency use. With their help, you can log into your account, untie the configured devices and add new ones. Keep these keys in a safe place, not as a screenshot on your smartphone or a text file on your computer.
As you can see, there are some nuances in using two-factor authentication, but they seem complicated only at first glance. What should be the ideal balance of protection and convenience, everyone decides for himself. But in any case, all the troubles are more than justified when it comes to the security of payment data or personal information that is not intended for prying eyes.
Where you can and should enable two-factor authentication, as well as what services support it, you can read.
1. A layer of mucus covering the entire surface of the mucous membrane. Mucin mucus binds HCl, adsorbs toxins, neutralizes mucopolysaccharides produced by the gastric epithelium.
2. Secretion of bicarbonate ions with pancreatic juice and bile.
3. Bicarbonate anions, synthesized by epithelial cells, neutralizing pH up to 7.0 near the surface of the mucous membrane.
4. The presence of PGE2 (regulate the protection of the mucous membrane) and PGI2 (provide adequate local blood flow).
5. Surfactant-like substances that cover the mucous membrane with a hydrophobic barrier.
6. Alkaline reaction of saliva and pancreatic juice.
7. Normal mechanism of inhibition of gastric secretion (antroduodenal acid brake).
8. Buffering capacity of food.
9. Active activity of the ovaries.
10. Mineralocorticoid hormones.
11. Factors promoting regeneration (migration of epithelial cells; proliferation and differentiation of cells from the gastric glands into functionally active cells).
Thus, summarizing the influence of protective factors, it should be noted that normally mucus is a gel containing acidic and neutral glycoproteins and water. It is mucus that is primarily the border between the cells of the mucous membrane and the contents of the stomach. It has an enveloping effect, preventing the effects of mechanical components of food.
The mucus buffer system neutralizes chemically active substances. In the lumen of the stomach, the constancy of the concentration of pepsin is maintained due to the properties of mucus to inhibit its reabsorption. With a stomach ulcer, despite the restriction of the secretory activity of the mucous membrane, secondary erosion is possible due to the qualitative or quantitative inferiority of protective factors (mucus formation, the consistency of the epithelium). On the contrary, with an ulcer of the duodenal bulb, the main factors are the increased formation of hydrochloric acid and pepsin.
With sufficient mucus and bicarbonate formation, the regeneration of the mucosal epithelium is not disturbed. However, only if there is sufficient blood flow in the mucous membrane, optimal regeneration of the epithelium and the formation of energy are possible to perform the above functions. PGI2 plays an essential role in maintaining optimal mucosal perfusion, and therefore in the formation of mucus and bicarbonate. The protective role of endogenous prostaglandins (PGE1, E2) contained in the gastric mucosa is manifested by a decrease in acid production and an increase in bicarbonate production. Stimulation of the production of endogenous prostaglandins reduces the ulcerogenic effect. Their cytoprotective effect is associated with the stimulation of mucus formation and the alkaline component of gastric juice, and the optimization of blood flow.
PGF2 has the ability to stabilize the membranes of lysosomes, mucosal epithelium, inhibit the activity of lysosomal enzymes, maintain a normal level of DNA in epithelial cells, thus preventing their desquamation.
PGE1 inhibits the action of protein synthesis inhibitors in the mucous membrane, which optimizes the reparative processes in it. A decrease in the production of endogenous prostaglandins leads to a decrease in blood flow in the gastric mucosa and a slowdown in the regeneration of the epithelium, which contributes to the unhindered action of aggressive factors.
